Product Name：ω-Agatoxin IVA
CAS No.：145017-83-0
Synonyms：瓊脂毒素 IVA
Catalog No.：211P01
Brand：HongTide（上海鴻肽生物）
Description：ω-Agatoxin IVA是一種有效的選擇性 P/Q型 Ca2+ 通道阻滯劑多肽，序列中含有48個(gè)氨基酸，并含有4對(duì)二硫鍵，ω-Agatoxin IVA對(duì)于 P 型和 Q 型 Ca2+ 通道，IC50 分別為 2 nM 和 90 nM。ω-Agatoxin IVA (IC50，30-225 nM) 抑制高鉀引起的谷氨酸胞吐作用和鈣流入。ω-Agatoxin IVA 還可以阻止高鉀誘導(dǎo)的 5-羥色胺和去甲腎上腺素的釋放，對(duì) L 型或 N 型鈣通道沒(méi)有影響。
ω- Agatoxin IVA is an effective selective P/Q type Ca2+channel blocker peptide with a sequence containing 48 amino acids and 4 pairs of disulfide bonds, ω- The IC50 of Agatoxin IVA for P-type and Q-type Ca2+channels is 2 nM and 90 nM, respectively. ω- Agatoxin IVA (IC50, 30-225 nM) inhibits high potassium induced glutamate exocytosis and calcium influx. ω- Agatoxin IVA can also prevent high potassium induced release of serotonin and norepinephrine, without affecting L-type or N-type calcium channels.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KKKCIAKDYGRCKWGGTPCCRGRGCICSIMGTNCECKPRLIMEGLGLA(Disulfide bonds between Cys4 and Cys20/Cys12 and Cys25/Cys19 and Cys36/Cys27 and Cys34) |
Sequence(3-letter code) | H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (Disulfide bonds between Cys4 and Cys20/Cys12 and Cys25/Cys19 and Cys36/Cys27 and Cys34) |
Peptide Structure | 
|
Molecular Formula | C217H360N68O60S10 |
Molecular Weight | 5202.24 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
手機(jī)： +86-18018095145 （同微信號(hào)）
QQ: 3259098395
郵箱：sales1@hongtide.com
關(guān)鍵字： ω-Agatoxin IVA;145017-83-0;瓊脂毒素 IVA;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。