CD8a產(chǎn)品信息
英文名稱:Cluster of differentiation 8
中文名稱:分化群8
靶點(diǎn)別稱:CD8 Antigens,CD8a,CD8 alpha
物種:Human / Mouse / Cynomolgus
屬性:Protein
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
CD8a分子背景
在免疫反應(yīng)中起重要作用的完整膜糖蛋白,在抵抗外部和內(nèi)部攻擊的反應(yīng)中具有多種功能。同時(shí)與T細(xì)胞受體(TCR)和抗原呈遞細(xì)胞(APC)呈遞的MHC I類蛋白相互作用。反過來,Src激酶LCK被募集到TCR-CD3復(fù)合物附近。在NK細(xì)胞中,細(xì)胞表面CD8A同源二聚體的存在提供了一種存活機(jī)制,允許多個(gè)靶細(xì)胞的結(jié)合和裂解。CD8A同二聚體分子還促進(jìn)活化淋巴細(xì)胞的存活和分化為記憶性CD8 T細(xì)胞。
關(guān)鍵字: CD8a;CD8a蛋白;分化群8;CD8 alpha;CD8a重組蛋白;
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