ENPP3產(chǎn)品信息
英文名稱:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
中文名稱:核苷酸內(nèi)焦磷酸酶/磷酸二酯酶家族成員-3
靶點別稱:ENPP3,CD203c,NPP3,E-NPP3,PD-Ibeta,NPPase,PDNP3
物種:Human / Mouse
屬性:Protein / Cell
標記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 50mM Tris, 150mM NaCl, pH 7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
ENPP3分子背景
人源NPP家族包含七名成員,根據(jù)其底物偏好可分為兩組。第一類包括核苷酸降解蛋白NPP1、3和4。NPP3(CD203c,ENPP3)在多個器官中表達,包括上皮和粘膜表面,尤其是嗜堿性粒細胞和肥大細胞??乖Y(jié)合的IgE激活嗜堿性粒細胞導致炎癥介質(zhì)的釋放和NPP3向細胞表面的快速上調(diào)。事實上,這種蛋白質(zhì)是通過流式細胞術診斷患者嗜堿性粒細胞過敏原敏感性的常見標志物。嗜堿性粒細胞和肥大細胞介導對某些病原體的反應,以及急性和慢性過敏反應。激活后,這些細胞釋放ATP,ATP以自分泌的方式進一步刺激它們。NPP3上調(diào)有助于降解ATP并抑制慢性過敏性炎癥(但不是急性反應)。
關鍵字: ENPP3;ENPP3蛋白;CD203c;CD203c蛋白;NPP3;
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