Integrin αvβ1產品信息
英文名稱:Integrin alpha-V/beta-1
中文名稱:整合素α-V/β-1復合體
靶點別稱:Integrin αvβ1,Integrin alpha V beta 1,ITGAV&ITGB1
物種:Human / Cynomolgus / Rat
屬性:Protein
標記:Biotin-labeled / Unconjugated
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 8.0 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
Integrin αvβ1分子背景
整合素α-5/β-1是纖維蛋白原的受體。整合素α-1/β-1、α-2/β-1,α-6/β-1和α-7/β-1是lamimin的受體。整合素α-4/β-1是VCAM-1的受體。它識別VCAM-1中的序列Q-I-D-S。整合素α-9/β-1是VCAM-1、細胞觸覺素和骨橋蛋白的受體。它識別細胞觸覺素中的序列A-E-I-D-G-I-E-L。整合素α-V/β-1也是玻連蛋白的受體。Beta-1整合素在多種配體中識別R-G-D序列。異構體2干擾異構體1,對細胞粘附和遷移(體外)產生顯性負面影響。當與α-7/β-1整合素結合時,調節(jié)細胞粘附和層粘連蛋白基質沉積。
關鍵字: Integrin αvβ1;整合素αvβ1;Integrin alpha V bet;αvβ1整合素;αvβ1 Integrin;
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