IL-33產(chǎn)品信息
英文名稱：Interleukin-33
中文名稱：白細(xì)胞介素-33
靶點(diǎn)別稱：IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV
物種：Human / Mouse / Cynomolgus
屬性：Protein
標(biāo)記：Biotin-labeled / Unconjugated
內(nèi)毒素（Endotoxin）
Less than 0.1 EU per μg by the LAL method.
無(wú)菌（Sterility）
The sterility testing was performed by membrane filtration method.
支原體（Mycoplasma）
Negative.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
IL-33分子背景
Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
IL-33用戶評(píng)價(jià)
關(guān)鍵字： IL-33;IL-33蛋白;白介素33;IL-33細(xì)胞因子;Interleukin-33;
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