LRRC15產(chǎn)品信息

英文名稱：Leucine-rich repeat-containing protein 15

中文名稱：富含亮氨酸重復(fù)序列蛋白-15

靶點(diǎn)別稱：Leucine-rich repeat-containing protein 15,LRRC15,LIB,hLib

物種：Human / Mouse / Cynomolgus / Rhesus macaque

屬性：Protein / Cell

標(biāo)記：Biotin-labeled / Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

LRRC15分子背景

LRRC15（富含亮氨酸重復(fù)序列的蛋白質(zhì)15）也被稱為L(zhǎng)IB和hLib。LRRC15在多種實(shí)體瘤中高度表達(dá)。LRRC15在許多實(shí)體瘤（如乳腺、頭頸部、肺、胰腺）的基質(zhì)成纖維細(xì)胞上表達(dá)，也直接在間充質(zhì)來(lái)源的癌癥細(xì)胞亞群（如肉瘤、黑色素瘤、膠質(zhì)母細(xì)胞瘤）上表達(dá)。TGFβ誘導(dǎo)活化的成纖維細(xì)胞（α-SMA+）和間充質(zhì)干細(xì)胞表達(dá)LRRC15。這些集體發(fā)現(xiàn)表明，LRRC15是一種新型的CAF和間充質(zhì)標(biāo)志物，可作為治療LRRC15陽(yáng)性間質(zhì)促纖維增生癥或間充質(zhì)來(lái)源癌癥的治療靶點(diǎn)。ABBV-085是一種針對(duì)LRRC15的含單甲基金抑制素E（MMAE）的抗體-藥物偶聯(lián)物（ADC），它作為單一療法或與標(biāo)準(zhǔn)護(hù)理療法相結(jié)合，對(duì)LRRC15中的異常陽(yáng)性/癌癥陰性和LRRC15癌癥陽(yáng)性模型表現(xiàn)出強(qiáng)大的臨床前療效。