中文名：6-巰基嘌呤 (6-MP)

英文名：Mercaptopurine (6-MP)

英文別名：3H-purine-6(7H)-thione

純度：10mM in DMSO

貨號：M409022

包裝：1ml

Cas號：50-44-2

存儲溫度：-80℃儲存

產(chǎn)品介紹：

Information

Mercaptopurine (6-MP) Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
In?vitro

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.

In?vivo

Cell?Data

cell?lines：

Concentrations：

Incubation?Time：

Powder?Purity:≥99%

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