中文名：馬替普林鹽酸鹽

英文名：Maprotiline HCl

英文別名：N-?methyl-?9,?10-?ethanoanthracene-?9(10H)?-?propanamine,hydrochloride (1:1)

純度：10mM in DMSO

貨號：M408267

包裝：1ml

Cas號：10347-81-6

存儲溫度：-80℃儲存

產(chǎn)品介紹：

Information

Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
In?vitro

Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum.

In?vivo

Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training.
Cell?Data

cell?lines：HUVEC, SH-SY5Y, IGR-N91 and IGR-NB8 cells

Concentrations：

Incubation?Time：

Powder?Purity:≥99%

查看阿拉丁官網(wǎng)此產(chǎn)品相關(guān)對應(yīng)頁面：https://www.aladdin-e.com/zh_cn/M408267.html