中文名：乙硫異酰胺

英文名：Ethionamide

英文別名：Bayer 5312;2-?ethyl-4-?pyridinecarbothioami?de

純度：10mM in DMSO

貨號(hào)：E408837

包裝：1ml

Cas號(hào)：536-33-4

存儲(chǔ)溫度：-80℃儲(chǔ)存

產(chǎn)品介紹：

Information

Ethionamide (Bayer 5312) is anantibioticused in the treatment of tuberculosis.
In?vitro

Ethionamide is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. Ethionamide mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. Ethionamide is activated by an EthA enzyme, leading to the formation of a Soxide metabolite that has considerably better activity than the parent drug. Ethionamide inhibits both biofilm formation and viability of mature biofilms. Ethionamide reduces the content of ergosterol in Cryptococcus spp. planktonic cells and destabilized or permeabilized the fungal cell membrane, leading to leakage of macromolecules. Ethionamide is in general toxic at concentrations above 0.50 mM to HepG2, Caco-2, and RAW macrophage cells, but the toxicity is drastically reduced when Ethionamide is loaded into the microparticles. Ethionamide shows a fast metabolization process in the presence of the thermally carbonized- Porous silicon (TCPSi) particles. Ethionamide is activated in Mycobacterium tuberculosis by the protein encoded by the gene Rv3854c. Ethionamide appear to disrupt cell wall biosynthesis and have at least one common cellular target, the enoyl-acyl carrier protein reductase InhA.

In?vivo

Cell?Data

cell?lines：

Concentrations：

Incubation?Time：

Powder?Purity:≥99%

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