中文名：Tucidinostat (Chidamide)
英文名：Tucidinostat (Chidamide)
英文別名：HBI-8000, CS-055;Benzamide, N-?(2-?amino-?4-?fluorophenyl)?-?4-?[[[(2E)-1-?oxo-?3-?(3-?pyridinyl)?-?2-?propen-?1-?yl]?amino]?methyl]?-
純度：10mM in DMSO
貨號：T409118
包裝：1ml
Cas號：1616493-44-7
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Tucidinostat (Chidamide, HBI-8000, CS-055) is a low nanomolar inhibitor ofHDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
In?vitro
Chidamide inhibits class I HDACs 1-3, as well as class IIb HDAC10, at low nanomolar concentrations. Chidamide significantly induces histone H3 acetylation in both HeLa human cervical adenocarcinoma cells and human PBMC. Cell growth inhibition studies performed with 18 human-derived tumor cell lines demonstrate that chidamide and MS-275 similarly inhibit the in vitro growth of most, but not all, tumor cells in the low micromolar concentration range. However, chidamide, and to a lesser extent MS-275, is significantly less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCC-HEL), indicating a differential cytotoxic response of normal cells versus cancerous cells to chidamide.
In?vivo
In HCT-8 colorectal carcinoma mice xenografts, Chidamide shows in vivo antitumor activity. Chidamide in the dose range of 12.5-50 mg/kg dose-dependently reduces tumor size and tumor weight, and the dose of 50 mg/kg produces similar or greater efficacy compared with the control drugs 5-fluorouracil(5-FU, 20 mg/kg) and MS-275 (25 mg/kg, which was reported as the maximum tolerated dose in xenograft models). However, chidamide is well-tolerated at the above doses in the tumor-bearing animals, whereas the control drugs cause significant weight loss.
Cell?Data
cell?lines：
Concentrations：0-400 nM
Incubation?Time：0-400 nM
Powder?Purity:≥98%
查看阿拉丁官網(wǎng)此產(chǎn)品相關(guān)對應(yīng)頁面：https://www.aladdin-e.com/zh_cn/T409118.html
關(guān)鍵字： HBI-8000, CS-055;Benzamide, N-?(2-?amino-?4-?fluorophenyl)?-?4-?[[[(2E)-1-?oxo-?3-?(3-?pyridinyl)?-?2-?propen-?1-?yl]?amino]?methyl]?-
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代碼：688179），專注于科研試劑的研發(fā)、生產(chǎn)和銷售，已陸續(xù)建立多個工廠和研發(fā)中心。作為領(lǐng)軍企業(yè)，阿拉丁始終堅(jiān)持質(zhì)量第一，連續(xù)13年被評為“最受歡迎試劑品牌”。
阿拉丁目前常備庫存試劑產(chǎn)品品種超過7萬種，SKU總數(shù)超過46萬，產(chǎn)品線涵蓋了化學(xué)試劑、生化試劑、藥靶配體、蛋白質(zhì)和抗體等多個領(lǐng)域，是國內(nèi)少數(shù)化學(xué)試劑到生物試劑全面發(fā)展的國產(chǎn)試劑品牌，產(chǎn)品同步發(fā)布在我們國內(nèi)（www.aladdin-e.com）和海外（www.aladdinsci.com）電商平臺。