中文名：BML 283,Ca 2+螯合劑
英文名：BAPTA-AM
中文別名：1,2-雙(2-氨基苯氧基)乙烷-N,N,N`,N`-四乙酸四乙酸甲酯|胞內(nèi)鈣熒光探針BAPTA-AM|1,2-雙(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸四(乙酸基甲基)酯|1,2-雙(2-氨基苯氧基)-乙烷-N,N,N,N'-四乙酸
英文別名：BAPTA-AM|126150-97-8|BAPTA/AM|acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate|BAPTA/AM(BAPTA-AM)|(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(2-{2-[bis
純度：95%
貨號(hào)：B115502
包裝：100mg、25mg
Cas號(hào)：126150-97-8
存儲(chǔ)溫度：-20°C儲(chǔ)存
產(chǎn)品介紹：
BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid? is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. Has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research.?
BAPTA-AM抑制自由基介導(dǎo)的毒性，增強(qiáng)非神經(jīng)細(xì)胞中細(xì)胞凋亡，保護(hù)神經(jīng)細(xì)胞免受缺血性損傷。它調(diào)節(jié)離子通道，阻止神經(jīng)Ca2+-激活K+通道電流。BAPTA-AM維持細(xì)胞內(nèi)Ca2+動(dòng)態(tài)平衡。
A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.
· 降低剪切后半胱氨酸蛋白酶-3升高水平
· 阻止細(xì)胞死亡，抑制ROS（活性氧化簇）產(chǎn)物，抑制半胱氨酸蛋白酶-8活性。
· 排除細(xì)胞內(nèi)Ca2+ ([Ca2+]i) 濃度變化對(duì)癲癇誘導(dǎo)影響
· 消除6-羥多巴胺(6-OHDA)誘導(dǎo)的[Ca2+]i增量水平
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關(guān)鍵字： 1,2-雙(2-氨基苯氧基)乙烷-N,N,N`,N`-四乙酸四乙酸甲酯;胞內(nèi)鈣熒光探針BAPTA-AM;1,2-雙(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸四(乙酸基甲基)酯;1,2-雙(2-氨基苯氧基)-乙烷-N,N,N,N'-四乙酸
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