中文名：他莫西芬

英文名：Tamoxifen

中文別名：三苯氧胺

英文別名：Tox21_500494|UPCMLD-DP027|(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine|(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE|1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene|GTPL5384|HMS3261D09|,citrate|2-(4-((

純度：≥99%

貨號：T137974

包裝：1g、5g、25g

Cas號：10540-29-1

存儲溫度：2-8°C儲存

產(chǎn)品介紹：

Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrμg that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Tamoxifen has been used to facilitate the recombination of ect2^flox allele in mouse organs⁹¹. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation⁹².

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