別名

eIF-2α Inhibitor II, Sal003 - CAS 301359-91-1 - Calbiochem,3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003

一般描述

A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo. A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.

重懸

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說(shuō)明

Raven, J.F., et al. 2008. J. Biol. Chem.283, 3097.
Baltzis, D., et al. 2007. J. Biol. Chem.282, 31675.
Kazemi, S., et al. 2007. Mol. Biol. Cell18, 3635.
Costa-Mattioli, M., et al. 2007. Cell129, 195.
Robert, F., et al. 2006. Mol. Biol. Cell17, 4632.