一般描述

4-Aminoindole is an indole derivative. Its cytokinin activity has been assessed by tobacco pith callus bioassay. 4-Aminoindole can be prepared by reacting 2,6-dinitrotoluene and N,N-dimethylformamide dimethylacetal in anhydrous DMF.

應(yīng)用

4-Aminoindole may be used to synthesize:
macrolactam tumour promoter indolactam Vtricyclic structure of 2-substituted-pyrrolo[2,3-h]quinolin-4-one4-azidoindole Reactant for preparation of:
Inhibitors of bacterial thymidylate synthaseMimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)Inhibitors of Gli1-mediated transcription in the Hedgehog pathwayProtein kinase C θ (PKCθ) inhibitorsIndolic non-peptidic HIV protease inhibitorsTransient receptor potential cation channel subfamily V member 1 (TRPV1) antagonistsCyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitorsShort chain 4-substituted indoles as potent αvβ3 antagonistLigands of serotonin transporter and 5-HT1A receptors