Product Name:TC14012
CAS No.:368874-34-4
Synonyms:激動劑多肽TC14012
Catalog No.:217P614
Brand:HongTide(上海鴻肽生物)
Description:TC 14012是CXCR4 拮抗劑和 ACKR3 (CXCR7) 激動劑多肽,也是一種擬肽 CXCR4 拮抗劑多肽,序列中含有14個氨基酸。TC 14012能阻斷 CXCR4 介導(dǎo)的 HIV 感染,IC50 值為 19.3 nM。 此外,TC 14012 (100 μg/ml) 抑制 CXCL12 誘導(dǎo)的慢性淋巴細胞白血病患者 B 細胞中 p42/44 MAPK 和 STAT3 的磷酸化。 TC 1412 是 C 端酰胺化的,這導(dǎo)致高血清穩(wěn)定性。 TC 14012 是 CXCR7 激動劑 (EC50 = 350 nM),可促進 β-抑制蛋白的募集和 Erk 1/2 磷酸化。
TC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist peptide, also a peptide like CXCR4 antagonist peptide with 14 amino acids in its sequence. TC 14012 can block CXCR4 mediated HIV infection with an IC50 value of 19.3 nM. In addition, TC 14012 (100 μ G/ml) inhibits the phosphorylation of p42/44 MAPK and STAT3 in B cells of chronic lymphocytic leukemia patients induced by CXCL12. TC 1412 is C-terminal amidated, which leads to high serum stability. TC 14012 is a CXCR7 agonist (EC50=350 nM) that can promote β- Inhibiting protein recruitment and Erk 1/2 phosphorylation.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | RR-{D-2Nal}-CY-{Cit}-K-{D-Cit}-PYR-{Cit}-CR-NH2(Disulfide bridge:Cys4-Cys13) |
Sequence(3-letter code) | H-Arg-Arg-{D-2-Nal}-Cys-Tyr-Cit-Lys-{D-Cit}-Pro-Tyr-Arg-Cit-Cys-Arg-NH2(Disulfide bridge:Cys4-Cys13) |
Peptide Structure |
|
Molecular Formula | C90H140N34O19S2 |
Molecular Weight | 2066.43 |
訂購聯(lián)系方式:
上海鴻肽生物科技有限公司
手機: +86-18018095145 (同微信號)
QQ: 3259098395
郵箱:sales1@hongtide.com
關(guān)鍵字: TC14012 ;368874-34-4;激動劑多肽TC14012;多肽;多肽合成;
上海鴻肽生物科技有限公司(簡稱:鴻肽生物)是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋:定制多肽、目錄多肽、氨基酸衍生物、小分子化合物;公司自成立以來,秉持“用質(zhì)量作船, 以服務(wù)為帆,為科研服務(wù)”的企業(yè)理念,為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。