Rabbit Anti-phospho-SHC1 (Ser36) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-SHC1 (Ser36)
IR:Immunogen Range:LP(p-S)PS
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:6464
Swiss Prot:P29353
Source:KLH conjugated Synthesised phosphopeptide derived from human SHC around the phosphorylation site of Ser36:LP(p-S)PS
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： phospho-SHC1 (Ser36);SHC (phospho S36);p-SHC(Ser36);p46;p52;SHC;p52SHC;SHC1_HUMAN;
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