Rabbit Anti-mTOR Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:mTOR
IR:Immunogen Range:2350-2440/2549
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:2475
Swiss Prot:P42345
Source:KLH conjugated synthetic peptide derived from human mTOR:2350-2440/2549
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Background:mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
Cross Reactive Species:Human
Mouse
Rat
"僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： mTOR;FKBP12;dJ576K7.1 ; FK506 binding prote;FK506 binding protei;FRAP2;FRAP1;MTOR_HUMAN;
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