Product Name:TPP-1
CAS No.: 2426685-25-6
Synonyms:有效抑制劑多肽TPP-1
Catalog No.:218P432
Brand:HongTide(上海鴻肽生物)
Description:TPP-1 是PD-1/PD-L1相互作用的有效抑制劑多肽,序列中含有22個(gè)氨基酸。TPP-1 與 PD-L1 特異性高親和力結(jié)合 (KD=95 nM)。動物模型中,TPP-1 通過再激活 T 細(xì)胞功能抑制腫瘤生長。在異種移植物小鼠模型中,TPP-1處理的小鼠的腫瘤生長比對照組低56%-71%。
TPP-1 is an effective inhibitor peptide of PD-1/PD-L1 interaction, with a sequence containing 22 amino acids. TPP-1 binds specifically to PD-L1 with high affinity (KD=95 nM). In animal models, TPP-1 inhibits tumor growth by reactivating T cell function. In the xenograft mouse model, the tumor growth of TPP-1 treated mice was 56% -71% lower than that of the control group.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | SGQYASYHCWCWRDPGRSGGSK |
Sequence(3-letter code) | H-Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys-OH |
Peptide Structure | |
Molecular Formula | C107H150N34O32S2 |
Molecular Weight | 2488.67 |
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關(guān)鍵字: 2426685-25-6;有效抑制劑多肽TPP-1;TPP-1;多肽;多肽合成;
上海鴻肽生物科技有限公司(簡稱:鴻肽生物)是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋:定制多肽、目錄多肽、氨基酸衍生物、小分子化合物;公司自成立以來,秉持“用質(zhì)量作船, 以服務(wù)為帆,為科研服務(wù)”的企業(yè)理念,為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。