Rabbit Anti-DCUN1D1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:DCUN1D1
IR:Immunogen Range:1-100/259
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:54165
Swiss Prot:Q96GG9
Source:KLH conjugated synthetic peptide derived from human DCUN1D1:1-100/259
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Chicken
Cow
Horse
僅供科研使用。不能用于人和動物治療等其它臨床診斷用
關鍵字： DCUN1D1;DCN1 defective i;DCN1 like protein 1;DCNL1;DCUN1L1;RP42;SCRO;DCNL1_HUMAN;
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