Rabbit Anti-GPR109A Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:GPR109A
IR:Immunogen Range:1-33/363
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:338442
Swiss Prot:Q8TDS4
Source:KLH conjugated synthetic peptide derived from human GPR109A/HM74A:1-33/363
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Cow
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： GPR109A;HM74A;HM74a;HM74b;NIACR1;Puma-g;PUMAG;HCAR2_HUMAN ;
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