Rabbit Anti-SLC7A5 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:SLC7A5
IR:Immunogen Range:101-200/507
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8140
Swiss Prot:Q01650
Source:KLH conjugated synthetic peptide derived from human SLC7A5:101-200/507
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:L-type amino acid transporter 1 (LAT1) is a multipass-membrane protein responsible for sodium-independent, high-affinity transport of large neutral amino acids. LAT1 functions as a disulfide-linked heterodimer with the amino acid transport protein CD98. LAT1 is expressed predominantly in adult lung and liver but is also expressed in brain, thymus, retina, testis, placenta, bone marrow and fetal liver. In the retina, LAT1 localizes to the blood-retinal-barrier (BRB) and mediates L-leucine transport from the blood to the retina. The devastating effects on the brain caused by phenylketonuria are due to the increased levels of LAT1 on the blood-brain-barrier in response to high concentrations of phenylalanine in the blood. LAT1 accepts the amino-acid related anticancer agent melphalan and plays a significant role in cell proliferation, differentiation, and invasion in esophageal squamous cell carcinoma.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Rabbit
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： SLC7A5;LAT1;4F2 LC;4F2 light chain;4F2LC;SLC7A5;CD98;LAT1_HUMAN;
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