Rabbit Anti-CaMKII delta Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CaMKII delta
IR:Immunogen Range:271-370/499
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:817
Swiss Prot:Q13557
Source:KLH conjugated synthetic peptide derived from Human CAMK2D/CaMKII delta:271-370/499
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated ?, ∫, ? and ?, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but phosphorylation by a CaMK is also required for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Mouse
Rat
Pig
Cow
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： CaMKII delta;CAM kinase 2 delta;CAM kinase II delt;CaM kinase II subuni;CAMK 2d;CAMK2D;CAMKD;KCC2D_HUMAN;
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