Rabbit Anti-Ube2G1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Ube2G1
IR:Immunogen Range:101-170/170
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7326
Swiss Prot:P62253
Source:KLH conjugated synthetic peptide derived from human Ube2G1/UBC7:101-170/170
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. In Saccharomyces cerevisiae, ubiquitin-like proteins include Rub1, Ula1, Uba3, Smt3, Ubc2, Ubc12 and Ubc9. Rub1 shares 53% homology with ubiquitin and requires activation via the E2 proteins, including Ula1, Uba3 and Ubc12 in order to conjugate to substrates directed to different proteolytic systems. Ubc4 catalyzes ubiquitination of IkBa in a phosphorylation and SCFB-TRCP dependent manner. In this particular reaction, E1 first transfers ubiquitin to the E2 component Ubc4, and Ubc4 then associates with E3 ligase, which conjugates the poly-ubiquitin chain on a target protein. In this fashion, the chain tags the IkBa for degradation by a proteasome thus lifting the inhibitory effect of IkBa on NFkB and allowing NFkB to enter the nucleus.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:50-200)
Cross Reactive Species:Mouse
Rat
Dog
Pig
Horse
Rabbit
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： Ube2G1;E217K;UBC7;UBC7 homolog yeast;UBE2G;Ube2g1;Ubiquitin conjugatin;UB2G1_HUMAN;
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