Rabbit Anti-CLDN11 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CLDN11
IR:Immunogen Range:150-207/207
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:18417
Swiss Prot:Q60771
Source:KLH conjugated synthetic peptide derived from mouse Claudin 11:150-207/207
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Oligodendrocyte specific protein (OSP)is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Mouse
Rat
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： CLDN11;Oligodendrocyte Spec;Oligodendrocyte ;Claudin 11;claudin11;OSP;CLD11_HUMAN;CLD11_MOUSE;
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