Rabbit  Anti-GSDMA Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:GSDMA

IR:Immunogen Range:21-120/445

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:284110

Swiss Prot:Q96QA5

Source:KLH conjugated synthetic peptide derived from human GSDMA:21-120/445 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Gasdermin is a 445 amino acid protein that localizes to the perinuclear region of the cytoplasm and belongs to the gasdermin family. Expressed predominately in tissues of the gastrointestinal tract and also present in skin and mammary gland, gasdermin functions to induce apoptosis and is thought to possess tumor suppression activity, specifically in gastric cancer cells. The gene encoding gasdermin maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Size:50ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
Horse

"僅供科研使用。不能用于人和動物治療等其它臨床診斷用！