Rabbit Anti-phospho-Girdin (Ser1417) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-Girdin (Ser1417)
IR:Immunogen Range:QK(p-S)LT
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:55704
Swiss Prot:Q3V6T2
Source:KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1417:QK(p-S)LT
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(1ug/test)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： phospho-Girdin (Ser1;Girdin (phospho S141;p-APE(Ser1417);CCDC88A;APE;GRDN;KIAA1212;GRDN_HUMAN;
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