Rabbit Anti-Phospho-Jak1 (Tyr1034 + Tyr1035) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Phospho-Jak1 (Tyr1034 + Tyr1035)
IR:Immunogen Range:KE(p-Y)(p-Y)TV
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3716
Swiss Prot:P23458
Source:KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035:KE(p-Y)(p-Y)TV
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(2μg /Test)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： Phospho-Jak1 (Tyr103;AK1 (phospho Y1034 +;p-JAK1 (phospho Y103;JAK 1A;JAK 1B;JAK1B Janus kinase ;JTK3;JAK1_HUMAN;
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