Rabbit Anti-TLR5 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:
Host:Rabbit
Target Protein:TLR5
IR:Immunogen Range:701-810/873
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:53791
Swiss Prot:Q9JLF7
Source:KLH conjugated synthetic peptide derived from mouse TLR5:701-810/873
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： TLR5;toll-like receptor 5;FLJ10052;MGC126430;MGC126431;TIL3;CD285;TLR5_MOUSE;
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