Rabbit Anti-FREAC3 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:FREAC3
IR:Immunogen Range:101-200/553
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2296
Swiss Prot:Q12948
Source:KLH conjugated synthetic peptide derived from human FOXC1/FREAC3:101-200/553
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.
Involvement in disease; Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3 (RIEG3); also known as Axenfeld-Rieger syndrome (ARS) or Axenfeld syndrome or Axenfeld anomaly. It is characterized by posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line. Other features may be hypertelorism (wide spacing of the eyes), hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Glaucoma is a progressive blinding condition that occurs in approximately half of patients with Axenfeld-Rieger malformations.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Horse
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： FREAC3;ARA;FKH L7;Forkhead (Drosophila;Forkhead;forkhead box C1;IGDA;FOXC1_HUMAN;
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