Rabbit Anti-FADD Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:FADD
IR:Immunogen Range:1-80/205
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8772
Swiss Prot:Q13158
Source:KLH conjugated synthetic peptide derived from human FADD:1-80/205
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： FADD;FADD_HUMAN;FAS-associated death;MORT1;GIG3;IMD90;Growth-inhibiting ge;Mediator of receptor;
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