Rabbit Anti-phospho-IRE1 (Ser724) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-IRE1 (Ser724)
IR:Immunogen Range:RH(p-S)FS
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2081
Swiss Prot:O75460
Source:KLH conjugated synthesised phosphopeptide derived from human IRE1 around the phosphorylation site of Ser724:RH(p-S)FS
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes. In response to stress, sensors for the ER mammalian cells activate IRE1α and IRE1β, which then results in the phosphorylation of JNK (Jun N-Terminal Kinase) and the activation of the cellular MAP kinase pathway
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Horse
Sheep
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用
關(guān)鍵字： phospho-IRE1 (Ser724;p-IRE1 (phospho S724;Endoplasmic reticulu;ERN 1;ERN1;ERN1_HUMAN;hIRE 1p;Inositol requiring 1;
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