Product Name：Endomorphin-1
CAS No.： 189388-22-5
Synonyms：內(nèi)嗎啡肽Endomorphin-1
Catalog No.：186P19
Brand：HongTide（上海鴻肽生物）
Description：內(nèi)嗎啡肽是兩種內(nèi)源性阿片肽。 Endomorphin-1和 Endomorphin-2是已知對 μ 阿片受體具有最高親和力和特異性的四肽。Endomorphin-1位于孤束核、腦室周圍下丘腦和下丘腦背內(nèi)側(cè)，存在于組胺能神經(jīng)元中，可調(diào)節(jié)鎮(zhèn)靜和喚醒行為 1。假定內(nèi)嗎啡肽是較大前體的裂解產(chǎn)物，但尚未鑒定這種多肽或蛋白質(zhì)。表達(dá) EM2 樣免疫反應(yīng)性的 Perikarya 存在于下丘腦后部，而表達(dá) EM1 樣免疫反應(yīng)性的 Perikarya 存在于下丘腦后部和孤束核 (NTS) 中。 EM1 樣免疫反應(yīng)性比 EM2 樣免疫反應(yīng)性更廣泛和更密集地分布在整個大腦中，而 EM2 樣免疫反應(yīng)性在脊髓中比 EM1 樣免疫反應(yīng)性更普遍。內(nèi)嗎啡肽參與調(diào)節(jié)傷害感受和自主神經(jīng)系統(tǒng)過程以及對壓力的反應(yīng)。
Endomorphin is two endogenous opioid peptides. Endomorphin-1 and Endomorphin-2 are known pairs μ Opioid receptors are tetrapeptides with the highest affinity and specificity. Endomorphin-1 is located in the Solitary nucleus, periventricular hypothalamus and dorsomedial hypothalamus, and in histaminergic neurons, which can regulate sedation and arousal behavior. Assuming that the endorphin peptide is a cleavage product of a larger precursor, this peptide or protein has not yet been identified. Perikarya expressing EM2 like immunoreactivity exists in the posterior hypothalamus, while Perikarya expressing EM1 like immunoreactivity exists in the posterior hypothalamus and Solitary nucleus (NTS). EM1 like immunoreactivity is more widely and densely distributed throughout the brain than EM2 like immunoreactivity, while EM2 like immunoreactivity is more common in the spinal cord than EM1 like immunoreactivity. Endomorphin is involved in the regulation of nociception, Autonomic nervous system processes and responses to stress.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YPWF-NH2 |
Sequence(3-letter code) | H-Tyr-Pro-Trp-Phe-NH2 |
Peptide Structure | 
|
Molecular Formula | C34H38N6O5 |
Molecular Weight | 610.72 |
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關(guān)鍵字： Endomorphin-1;189388-22-5;內(nèi)嗎啡肽Endomorphin-1;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。