Host:Rabbit
Target Protein:MDR1
IR:Immunogen Range:21-100/1272
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5243
Swiss Prot:P21447
Source:KLH conjugated synthetic peptide derived from human MDR1:21-100/1272
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg/Test)
ICC(1:100)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： MDR1;ABCB1;gp170;P gp; p-GP;MDR1_HUMAN;PGY1;CLCS;
上海滬震實業(yè)有限公司是一家集研發(fā)、生產(chǎn)和銷售于一體的生命科學實驗室產(chǎn)品生物科技企業(yè)。主營產(chǎn)品：試劑盒，ELISA試劑盒，抗體，重組蛋白，血清，胎牛血清，細胞，原代細胞 細胞培養(yǎng)試劑，常用生化試劑。