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Anti-HLA-DQA1 antibody  -組織相容性抗原DQA1重組兔單克隆抗體,HLA-DQA1
  • Anti-HLA-DQA1 antibody  -組織相容性抗原DQA1重組兔單克隆抗體,HLA-DQA1
  • Anti-HLA-DQA1 antibody  -組織相容性抗原DQA1重組兔單克隆抗體,HLA-DQA1

Anti-HLA-DQA1 antibody -組織相容性抗原DQA1重組兔單克隆抗體

價格 1580 2680
包裝 50ul 100ul
最小起訂量 50ul
發(fā)貨地 上海
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更新日期 2024-12-23
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產(chǎn)品詳情

中文名稱:Anti-HLA-DQA1 antibody -組織相容性抗原DQA1重組兔單克隆抗體英文名稱:HLA-DQA1
品牌: 滬震生物產(chǎn)地: 中國/上海
保存條件: -20°C純度規(guī)格: > 99%
產(chǎn)品類別: 抗體 一抗
抗體名: CD; CELIAC1; DC 1 alpha chain; DC alpha; DC-1 alpha chain; DC-alpha; DC1, included; DQ alpha 1 chain; DQ-A1; DQ-DRW9 alpha chain; DQA1_HUMAN; FLJ27088; FLJ27328; Gluten-sensitive enteropathy (celiac disease); GSE; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA class II histocompatibility antigen, DQ(W3) alpha chain; HLA-DCA; HLA-DQA; HLA-DQA1; HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1; HLADC histocompatibility type; Immune response antigens HIa, included; leucocyte antigen DQA1; leukocyte antigen alpha chain; Major histocompatibility complex, class II, DQ alpha 1; MGC149527; MHC class II antigen; MHC class II DQA1; MHC class II HLA-D alpha glycoprotein; MHC class II HLA-DQ alpha 1; MHC class II surface glycoprotein; MHC HLA-DQ alpha; OTTHUMP00000029141; OTTHUMP00000176885; OTTHUMP00000178551; OTTHUMP00000178552; OTTHUMP00000233817. 靶點: 詳見說明書
宿主: Rabbit適應(yīng)物種: 詳見說明書
克隆性: 詳見說明書濃度: 1mg/ml
應(yīng)用范圍: WB=1:500-2000 IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.標(biāo)識物: 詳見說明書
形態(tài): 液體亞型: IgG1
免疫原: 詳見說明書貨號: HZ-R54201
用途范圍: 科研使用規(guī)格: 50ul/100ul/200ul
是否進(jìn)口: 是否單克隆: 詳見說明書
保質(zhì)期: 12個月抗原來源: 詳見說明書
標(biāo)記物: 詳見說明書產(chǎn)品用途: WB=1:500-2000 IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
2024-12-23 Anti-HLA-DQA1 antibody -組織相容性抗原DQA1重組兔單克隆抗體 HLA-DQA1 50ul/1580RMB;100ul/2680RMB 1580 滬震生物 中國/上海 -20°C > 99% 抗體 一抗

Host:Rabbit

Target Protein:HLA-DQA1

IR:Immunogen Range:

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:3117

Swiss Prot:P01909

Source:KLH conjugated synthetic peptide derived from human HLA-DQA1: 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
IP(1:10-50)
IHC-P(1:50-200)
IHC-F(1:50-200)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat
.

搜狗截圖23年04月21日1146_70.png

本產(chǎn)品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用!

















































































































































關(guān)鍵字: CD;CELIAC1;DC alpha;DC1;included;

公司簡介

上海滬震實業(yè)有限公司是一家集研發(fā)、生產(chǎn)和銷售于一體的生命科學(xué)實驗室產(chǎn)品生物科技企業(yè)。主營產(chǎn)品:試劑盒,ELISA試劑盒,抗體,重組蛋白,血清,胎牛血清,細(xì)胞,原代細(xì)胞 細(xì)胞培養(yǎng)試劑,常用生化試劑。
成立日期 2014-05-08 (11年) 注冊資本 100萬元整
員工人數(shù) 10-50人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 生化試劑,細(xì)胞培養(yǎng),蛋白組學(xué),分子生物學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 工廠,試劑,定制,服務(wù)
  • 上海滬震實業(yè)有限公司
VIP 3年
  • 公司成立:11年
  • 注冊資本:100萬元整
  • 企業(yè)類型:有限責(zé)任公司(國內(nèi)合資)
  • 主營產(chǎn)品:ELISA試劑盒,抗體,細(xì)胞系,原代細(xì)胞,細(xì)胞培養(yǎng)試劑,重組蛋白
  • 公司地址:松江區(qū)
詢盤

Anti-HLA-DQA1 antibody -組織相容性抗原DQA1重組兔單克隆抗體相關(guān)廠家報價

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詢價
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