Product Name：Gramicidin
CAS No.：1405-97-6
Synonyms：Gramicidin A；短桿菌肽A
Catalog No.：218P141
Brand：HongTide（上海鴻肽生物）
Description：短桿菌肽A是由短芽孢桿菌產(chǎn)生的一種抗生素，為線狀十五肽，N端甲酰化封閉氨基，C端是醛基。短桿菌肽A能夠殺死某些微生物．兩個(gè)短桿菌肽A分子從膜兩側(cè)相對(duì)插入可形成穿膜通道，提高生物膜對(duì)某些一價(jià)陽離子的通透性，使這些物質(zhì)順濃度梯度通過細(xì)胞膜，不過短桿菌肽A并不顯著提高運(yùn)輸速度。研究顯示短桿菌肽A能抑制T7噬菌體DNA的轉(zhuǎn)錄，抑制膜結(jié)合的表皮腺苷酸三磷酸酶活性和體外阻抑人淋巴細(xì)胞轉(zhuǎn)化。在大鼠動(dòng)物模型中能延長心臟移植存活率。
Gramicidin A is an antibiotic produced by Bacillus subtilis, which is a linear pentapeptide with N-terminal formylation blocking amino group and C-terminal aldehyde group. Short peptide A can kill certain microorganisms. Two short peptide A molecules can be inserted relative to each other from both sides of the membrane to form transmembrane channels, improving the permeability of the biofilm to certain monovalent cations, allowing these substances to pass through the cell membrane in a concentration gradient. However, short peptide A does not significantly improve transportation speed. Studies have shown that short peptide A can inhibit the transcription of T7 bacteriophage DNA, inhibit membrane bound epidermal adenosine triphosphatase activity, and inhibit human lymphocyte transformation in vitro. It can prolong the survival rate of heart transplantation in rat animal models.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | For-VGA-d-LA-d-VVVWLW-d-LW-d-LWG-ol |
Sequence(3-letter code) | For-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-Gly-ol |
Peptide Structure | 
|
Molecular Formula | C99H140N20O17 |
Molecular Weight | 1882.3 |
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關(guān)鍵字： 1405-97-6;Gramicidin A;短桿菌肽A;Gramicidin;多肽;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。