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Description
Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors.
Catalog No.
DHD72201
Host species
Homo sapiens
Species reactivity
Human
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Concentration
0.63 mg/ml
Purity
>95%
Clonality
Monoclonal
Isotype
IgG1-kappa
Applications
Research Grade Biosimilar
Target
CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27
Purification
Protein A or G purified from cell culture supernatant.
Endotoxin level
Please contact with the lab for this information.
Expression system
XtenCHO
Accession
P26842
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Alternative Names
1F5, CDX-1127, CAS: 1393344-72-3
Note
For research use only. Not suitable for clinical or therapeutic use.
關(guān)鍵字： Varlilumab;伐立魯單抗;1393344-72-3;TNFRSF7, T14;CD27;
武漢佰樂(lè)博生物（Biolab Reagents）由五位畢業(yè)于華中科技大學(xué)，華中農(nóng)業(yè)大學(xué)，武漢大學(xué)等知名高校，且具有二十年工作經(jīng)驗(yàn)的生命科學(xué)領(lǐng)域頂級(jí)研究者創(chuàng)立于2021年，憑借豐富的產(chǎn)品開發(fā)經(jīng)驗(yàn)，利用全球領(lǐng)先的技術(shù)平臺(tái)，引進(jìn)和整合全球高品質(zhì)的蛋白、抗體和試劑盒產(chǎn)品。目前，佰樂(lè)博生物作為法國(guó)AntibodySystem和ProteoGenix在亞洲的獨(dú)家總代理，提供近30,000種生命科學(xué)試劑，核心產(chǎn)品涵蓋蛋白、抗體和試劑盒，旨在為科研工作者提供專業(yè)、全面、可靠的試劑支持，推動(dòng)生命科學(xué)研究的深入發(fā)展。