Product Name：Linaclotide
CAS No.：851199-59-2；851199-60-5
Synonyms：linaclotide (usan)；利那洛肽
Catalog No.：218P053
Brand：HongTide（上海鴻肽）
Description：利那洛肽是一種鳥苷酸環(huán)化酶C激動劑，結構為含14個氨基酸的多肽。該藥物多肽能通過與腸道上皮局部的GC-C受體結合發(fā)揮作用，活化后的GC-C受體誘導體內cGMP濃度增加，一方面可以刺激腸液的分泌并促進胃腸活動，導致患者排便次數(shù)增多；另一方面可以減少痛覺神經活性，進而減少患者腸道疼痛。
Linaclotide is a guanylate cyclase C agonist with a structure of a peptide containing 14 amino acids. The drug peptide can play a role by binding to local GC-C receptors in the intestinal epithelium, and the activated GC-C receptors can induce an increase in the concentration of cGMP in the body. On the one hand, it can stimulate the secretion of intestinal fluid and promote gastrointestinal activity, leading to an increase in the number of stools in patients; On the other hand, it can reduce pain sensory nerve activity, thereby reducing intestinal pain in patients.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | CCEYCCNPACTGCY(Disulfide bond:Cys1-Cys6, Cys2 -Cys10,Cys5-Cys13) |
Sequence(3-letter code) | H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bond:Cys1-Cys6, Cys2-Cys10,Cys5-Cys13) |
Peptide Structure |  |
Molecular Formula | C59H79N15O21S6 |
Molecular Weight | 1526.74 |
訂購聯(lián)系方式：
上海鴻肽生物科技有限公司
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上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產品研發(fā)、生產、銷售以及技術轉讓為主要業(yè) 務科技公司。公司現(xiàn)有產品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質量作船， 以服務為帆，為科研服務”的企業(yè)理念，為國內外眾多科研工作者提供了優(yōu)質的服務及產品。