Product Name:AUNP-12
CAS No.:1353563-85-5
Synonyms:抑制劑多肽AUNP-12
Catalog No.:1353563-85-5
Brand:HongTide
Description:AUNP-12是一種新型的免疫檢查點(diǎn)調(diào)節(jié)劑,是PD-1信號(hào)通路的抑制劑多肽,序列中含有29個(gè)氨基酸,肽鏈中具有分支結(jié)構(gòu),賴氨酸側(cè)鏈接上一個(gè)7個(gè)氨基酸的支鏈。在表達(dá)hPDL2的HEK293細(xì)胞中,對(duì)淋巴細(xì)胞增殖和效應(yīng)功能方面對(duì)PD-L1和PD-L2表現(xiàn)出等效的拮抗作用。EC50為0.72 nM;在表達(dá)hPDL1的MDA-MB231細(xì)胞中,PBMC增殖試驗(yàn)中,EC50為0.41 nM。
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code)
EKIQAKPALQTVRFK(FSESTNS)FSESTNS
Sequence(3-letter code)
H-Glu-Lys-Ile-Gln-Ala-Lys-Pro-Ala-Leu-Gln-Thr-Val-Arg-Phe-Lys(Phe-Ser-Glu-Ser-Thr-Asn-Ser)-Phe-Ser-Glu
-Ser-Thr-Asn-Ser-OH
Peptide Structure
Molecular Formula
C142H225N39O49
Molecular Weight
3262.58
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鴻肽生物