別名
Sulindac Sulfide - CAS 32004-67-4 - Calbiochem,(Z)-5-Fluoro-2-methyl-1-[ p-(methylthio)benzylidene]indene-3-acetic Acid
一般描述
A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 μM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L. An active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1; COX-1; ID50 = 0.5 μM) relative to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 μM). Reduces Aβ42 production independently of COX inhibition.
生化/生理作用
Cell permeable: yes ID50 = 500 nM against COX-1 Product does not compete with ATP. Reversible: no
其他說明
Weggen, S., et al. 2001. Nature414, 212.Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.Herrmann, C., et al. 1998. Oncogene 17, 1769.Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.Arber, N., et al. 1997. Gastroenterology 113, 1892.Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
聯(lián)系商家時(shí)請(qǐng)?zhí)峒癱hemicalbook,有助于交易順利完成!