產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | 規(guī)格 | CAS號(hào) | 型號(hào) |
Busulfan | 10mM (in 1mL DMSO) 50mg | 55-98-1 | EY-Y0165391 |
Cas No.55-98-1
別名
化學(xué)名 4-methylsulfonyloxybutyl methanesulfonate
分子式 C6H14O6S2
分子量 246.3
溶解度 ≥ 12.3mg/mL in DMSO
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
DNA alkylating agent is attached to the guanine base of DNA and stops tumor growth by crosslinking guanine nucleobases in DNA double-helix strands and causes DNA damage [1].
In normal human diploid WI38 fibroblasts, busulfan (7.5-120 μM) induced senescence in a dose-dependant way, which was associated with prolonged activation of c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38) and extracellular signal-regulated kinase (Erk) [2]. The induction of senescence was initiated by the transient depletion of intracellular glutathione (GSH) and then an increase in reactive oxygen species (ROS) production, which activated the Erk and p38 MAPK pathway [1].
In the adult mouse testis, busulfan induced apoptosis and decreased testis weight. In the first week, apoptosis mainly occured to spermatogonia. In the following week, spermatogonia-specific markers Stra 8 and c-kit were reduced but Gli I remained constant, which indicated apoptosis of differentiating type A spermatogonia [3].
References:
[1]. Probin V, Wang Y, Zhou D. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med, 2007, 42(12): 1858-1865.
[2]. Probin V, Wang Y, Bai A, et al. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism. J Pharmacol Exp Ther, 2006, 319(2): 551-560.
[3]. Choi YJ, Ok DW, Kwon DN, et al. Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. FEBS Lett, 2004, 575(1-3): 41-51.
關(guān)鍵字： 55-98-1;C6H14O6S2;Busulfan;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷(xiāo)售企業(yè)，公司自成立以來(lái)，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運(yùn)用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類(lèi)大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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