價(jià)格 | 詢價(jià) |
包裝 | 1盒 |
最小起訂量 | 1盒 |
發(fā)貨地 | 上海 |
更新日期 | 2024-12-25 |
中文名稱:25-hydroxy Cholesterol-d6 | 英文名稱:25-hydroxy Cholesterol-d6 |
CAS:88247-69-2 | 品牌: 一研 |
保存條件: Store at -20°C | 產(chǎn)品類別: 抑制劑 |
Cas : 88247-69-2 |
產(chǎn)品屬性:
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
25-hydroxy Cholesterol-d6 | 500 μg 1 mg 5 mg | 88247-69-2 | EY-Y0165194 |
Cas No.88247-69-2
別名 N/A
化學(xué)名 N/A
分子式 C27H40D6O2
分子量 408.7
溶解度 DMF: 2 mg/ml,DMSO: 100 μg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 500 μg/ml
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
25-hydroxy Cholesterol contains six deuterium atoms at the 26, 26, 26, 27, 27, and 27 positions. It is intended for use as an internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-mass spectrometry. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.1 It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.2 Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.3,4,5
1.Adams, C.M., Reitz, J., De Brabander, J.K., et al.Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsJ. Biol. Chem.279(50)52772-52780(2004) 2.Bischoff, P.L., Holl, V., Coelho, D., et al.Apoptosis at the interface of immunosuppressive and anticancer activities: The examples of two classes of chemical inducers, oxysterols and alkylating agentsCurr. Med. Chem.7(7)693-713(2000) 3.McDonald, J.G., and Russell, D.W.Editorial: 25-Hydroxycholesterol: A new life in immunologyJournal of Leukocyte Biology88(6)1071-1072(2010) 4.Bauman, D.R., Bitmansour, A.D., McDonald, J.G., et al.25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A productionProc. Natl. Acad. Sci. USA106(39)16764-16769(2009) 5.Bensinger, S.J., Bradley, M.N., Joseph, S.B., et al.LXR signaling couples sterol metabolism to proliferation in the acquired immune responseCell13497-111(2008)
成立日期 | 2014-06-05 (11年) | 注冊(cè)資本 | 100 |
員工人數(shù) | 50-100人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
主營(yíng)行業(yè) | 生化試劑,抗體,細(xì)胞培養(yǎng),分子生物學(xué),免疫安全 | 經(jīng)營(yíng)模式 | 工廠,試劑 |
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西安瑞譜源生物技術(shù)有限公司
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2024-12-24 | |
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VIP13年
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安徽諾全藥業(yè)有限公司
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2024-12-18 | |
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上海阿拉丁生化科技股份有限公司
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2024-10-31 |