產品屬性：
產品名稱 | 規(guī)格 | CAS號 | 型號 |
ATB-346 | 10mM (in 1mL DMSO) 10mg 50mg 100mg | 1226895-20-0 | EY-Y0165127 |
Cas No.1226895-20-0
別名 N/A
化學名 4-carbamothioylphenyl 2-(6-methoxynaphthalen-2-yl)propanoate
分子式 C21H19NO3S
分子量 365.45
溶解度 ≥ 18.27mg/mL in DMSO
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
ATB-346 is a hydrogen sulphide-releasing anti-inflammatory drug [1].
ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) and shows a markedly reduced toxicity than its parent compound naproxen. In the airpouch model, ATB-346 significantly inhibited the PGE2 level and completely suppressed the whole blood TXB2 synthesis without causing gastric damage. In rats with adjuvant-Induced arthritis, administration of ATB-346 reduced the paw volume on days 14 and 21 notably. ATB-346 did not exert any damage or bleeding in the stomach or small intestine while naproxen caused bleeding in the small intestine. Besides that, administration of naproxen twice daily for 5 days in rats resulted in extensive damage in the small intestine. In contrast, same dose of ATB-346 caused quite little damage over the treatment of the 5 days [1].
References:
[1] Wallace J L, Caliendo G, Santagada V, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). British journal of pharmacology, 2010, 159(6): 1236-1246.
關鍵字： 1226895-20-0;C21H19NO3S;ATB-346;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學、分子生物學和常規(guī)生化試劑等為一體的科研產品銷售企業(yè)，公司自成立以來，秉承""全心全意服務于科研工作者""的企業(yè)理念，立足生物科技領域，運用生物技術和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構、高等院校、科研院所、企事業(yè)單位提供優(yōu)質的產品，服務生物科技領域的科學研究人員。
公司具有對普通貨物、冷藏及冷凍倉庫的存儲、包裝及運輸能力。
公司將始終堅持信譽立業(yè)、以人為本、質量保證、誠信服務的宗旨，不斷拼搏，開拓進取，與各界朋友攜手共創(chuàng)美好未來。