產(chǎn)品屬性:
產(chǎn)品名稱
規(guī)格
CAS號
型號
5-(N,N-Hexamethylene)-amiloride
5mg 10mg 50mg
1428-95-1
EY-Y0165069
Cas No.1428-95-1
別名 N/A
化學(xué)名 N/A
分子式 C12H18ClN7O
分子量 311.77
溶解度 DMSO: 100 mg/mL (320.75 mM)
儲存條件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 產(chǎn)品描述: 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2]. Na+/H+ exchanger[1]EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]
[1]. Rich IN, et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L, et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. Epub 2006 Jul 3.
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