產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
Filipin II | 500μg 2.5mg | 38620-77-8 | EY-Y0164895 |
Cas No.38620-77-8
別名 N/A
化學(xué)名 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-hexyl-17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,23E,25E-pentaen-2-one
分子式 C35H58O10
分子量 638.8
溶解度 Soluble in DMSO, DMF, Ethanol, Methanol
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]
Reference:
[1]. Bergy, M.E., and Eble, T.E. The filipin complex. Biochemistry 7(2), 653-659 (1968).
[2]. Balcavage, W.X., Beale, M., Chasen, B., et al. Effect of filipin on rat-liver and yeast mitochondria. Biochim. Biophys. Acta. 162(4), 525-532 (1968).
[3]. Sessa, G., and Weissmann, G. Effects of four components of the polyene antibiotic, filipin, on phospholipid spherules (liposomes) and erythrocytes. J. Biol. Chem. 243(16), 4364-4371 (1968).
關(guān)鍵字： 38620-77-8;C35H58O10;Filipin II;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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