產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
MitoTEMPO (hydrate) | 1mg 5mg 10mg 25mg | 1569257-94-8 | EY-Y0164884 |
Cas No.1569257-94-8
別名 N/A
化學(xué)名 2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio)acetyl]amino]-1-piperidinyloxy, monochloride, monohydrate
分子式 C29H35N2O2P?Cl [H2O]
分子量 528
溶解度 DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 15 mg/ml,PBS (pH 7.2): 5 mg/ml
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.[2][3][4]
Reference:
[1]. Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology & Medicine 51(7), 1289-1301 (2011).
[2]. Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14(10), 1176-1189 (2009).
[3]. Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation Research 107(1), 106-116 (2010).
[4]. Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radical Biology & Medicine 49(10), 1550-1560 (2010).
Product Citations
關(guān)鍵字： 1569257-94-8;C29H35N2O2P?Cl [H2O];MitoTEMPO (hydrate);
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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