別名
(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine
一般描述
BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.
應(yīng)用
BL-1249 has been used: as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissuesas a TWIK related potassium channel?(TREK2) modulator and in U-2 OS osteosarcoma cell lineas a TREK1 and TREK2 activator in mice.
生化/生理作用
BL-1249 also activates TWIK related potassium channel 2?(TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening. BL-1249 is a putative activator of potassium TREK-1 channel.
特點和優(yōu)勢
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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