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Cathepsin Inhibitor 1,Cathepsin Inhibitor 1
  • Cathepsin Inhibitor 1,Cathepsin Inhibitor 1

225120-65-0Cathepsin Inhibitor 1

價(jià)格 詢價(jià)
包裝 1盒
最小起訂量 1盒
發(fā)貨地 上海
更新日期 2024-12-23
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產(chǎn)品詳情

中文名稱:Cathepsin Inhibitor 1英文名稱:Cathepsin Inhibitor 1
CAS:225120-65-0品牌: 一研
保存條件: Store at -20°C產(chǎn)品類別: 抑制劑
Cas : 225120-65-0
2024-12-23 Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 1盒/RMB 一研 Store at -20°C 抑制劑

產(chǎn)品屬性:

產(chǎn)品名稱

規(guī)格

CAS號(hào)

型號(hào)

Cathepsin Inhibitor 1

5mg 100mg

225120-65-0

EY-Y0163998

Cas No.225120-65-0

別名

化學(xué)名 5-tert-butyl-N-[(2S)-3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl]-2-methylpyrazole-3-carboxamide

分子式 C20H24ClN5O2

Cathepsin Inhibitor 1.png

分子量 401.89

溶解度 Soluble in DMSO

儲(chǔ)存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
pIC50: 7.9, 6.7, 6.0, 5.5 and 5.2 for Cathepsin (L, L2, S, K, B), respectively

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin. Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. The lysosomal cysteine protease2 Cathepsin L (CatL) is found to be a potential target for intervention in treatment of osteoarthritis. After secreted into the extracellular matrix, CatL can degrade proteoglycans such as aggrecan4 and type II collagen, which are the major components of articular cartilage.

In vitro: The CatL pIC50 value of Cathepsin Inhibitor 1 was found to exceed that of its analog by 1.6 units. Moreover, CatS (ΔpIC50 = -0.1) and CatL2 (ΔpIC50 = 0.5) were much less sensitive to the structural change of Cathepsin Inhibitor 1, leading to an improved selectivity profile relative to its analog. Cathepsin Inhibitor 1 was as least as selective with respect to CatB and CatS as previously described CatL inhibitors. The crystal structure of its another analog bound to CatL provided the rationale for the SAR observed for Cathepsin Inhibitor 1. The 1-methyl group of the pyrazole made some contact with Leu69 and appeared to force the pyrazole ring out of co-planarity with the amide, likely functioning as a conformational lock [1].

In vivo: So far, there is no in vivo animal data available for Cathepsin Inhibitor 1 is an inhibitor of Cathepsin.

Clinical trial: N/A

Reference:

[1] Asaad N, Bethel PA, Coulson MD, Dawson JE, Ford SJ, Gerhardt S, Grist M, Hamlin GA, James MJ, Jones EV, Karoutchi GI, Kenny PW, Morley AD, Oldham K,Rankine N, Ryan D, Wells SL, Wood L, Augustin M, Krapp S, Simader H, Steinbacher S. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3.


關(guān)鍵字: 225120-65-0;C20H24ClN5O2;Cathepsin Inhibitor ;

公司簡(jiǎn)介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來(lái),秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念,立足生物科技領(lǐng)域,運(yùn)用生物技術(shù)和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。 公司具有對(duì)普通貨物、冷藏及冷凍倉(cāng)庫(kù)的存儲(chǔ)、包裝及運(yùn)輸能力。 公司將始終堅(jiān)持信譽(yù)立業(yè)、以人為本、質(zhì)量保證、誠(chéng)信服務(wù)的宗旨,不斷拼搏,開(kāi)拓進(jìn)取,與各界朋友攜手共創(chuàng)美好未來(lái)。
成立日期 2014-06-05 (11年) 注冊(cè)資本 100
員工人數(shù) 50-100人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 生化試劑,抗體,細(xì)胞培養(yǎng),分子生物學(xué),免疫安全 經(jīng)營(yíng)模式 工廠,試劑
  • 上海一研生物科技有限公司
VIP 3年
  • 公司成立:11年
  • 注冊(cè)資本:100
  • 企業(yè)類型:營(yíng)業(yè)執(zhí)照
  • 主營(yíng)產(chǎn)品:、ELISA試劑盒、PCR檢測(cè)試劑盒、生化檢測(cè)試劑盒、標(biāo)準(zhǔn)品、抗體、細(xì)胞等
  • 公司地址:上海市閔行區(qū)莘福路2號(hào)樓
詢盤

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