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BH3I-1,BH3I-1
  • BH3I-1,BH3I-1

300817-68-9BH3I-1

價格 詢價
包裝 1盒
最小起訂量 1盒
發(fā)貨地 上海
更新日期 2024-12-25
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產(chǎn)品詳情

中文名稱:BH3I-1英文名稱:BH3I-1
CAS:300817-68-9品牌: 一研
保存條件: Store at -20°C產(chǎn)品類別: 抑制劑
Cas : 300817-68-9
2024-12-25 BH3I-1 BH3I-1 1盒/RMB 一研 Store at -20°C 抑制劑

產(chǎn)品屬性:

產(chǎn)品名稱

規(guī)格

CAS

型號

BH3I-1

2mg 5mg 10mg 25mg 50mg

300817-68-9

EY-Y0163935

Cas No.300817-68-9

別名

化學(xué)名 (E)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid

分子式 C15H14BrNO3S2

BH3I-1.png

分子量 400.31

溶解度 40mg/mL in DMSO

儲存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
IC50: 293.95 μM

BH3I-1 is an inhibitor of Bcl-2 or Bcl-XL.

It has been reported that a disregulation of the Bcl-2/ Bcl-XL family proteins may result in the development of cancer, since the failure of the inactivation of pro-apoptotic pathways, or the activation of anti-apoptotic pathways, may occur in the regulation processes.

In vitro: The Bcl-2 inhibitors BH3I-1 and it analog BH3I-2 had been applied as lead compounds to find possible Bcl-2 or Bcl-X(L) inhibitors by using computer-assisted screening of in-house database. The identified compounds were further studied regarding their possible application as a drug. It was found that the induction of apoptosis, which was shown as number of hypodiploid cells, was increased by adding BH3I-1 and it analog BH3I-2 to Bjab Bcl-XL and Bjab neo/mock cells. In addition, the effects of the pro-apoptotic proteins Bax and Bak on the induction of apoptosis via BH3I-1 and it analog BH3I-2 were investigated with a variety of knockout cell lines, and resulted showed that the presence or absence of Bak or Bax has no significant influence on the amount of apoptotic events induced by BH3I-1 and it analog BH3I-2 [1].

In vivo: Currently, there is no animial in vivo data reported.

Clinical trial: Up to now, BH3I-1 is still in the preclinical development stage.

Reference:

[1] Füllbeck M,Gebhardt N,Hossbach J,Daniel PT,Preissner R. Computer-assisted identification of small-molecule Bcl-2 modulators. Comput Biol Chem.2009 Dec;33(6):451-6.


關(guān)鍵字: 300817-68-9;C15H14BrNO3S2;BH3I-1;

公司簡介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來,秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念,立足生物科技領(lǐng)域,運(yùn)用生物技術(shù)和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。 公司具有對普通貨物、冷藏及冷凍倉庫的存儲、包裝及運(yùn)輸能力。 公司將始終堅(jiān)持信譽(yù)立業(yè)、以人為本、質(zhì)量保證、誠信服務(wù)的宗旨,不斷拼搏,開拓進(jìn)取,與各界朋友攜手共創(chuàng)美好未來。
成立日期 2014-06-05 (11年) 注冊資本 100
員工人數(shù) 50-100人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 生化試劑,抗體,細(xì)胞培養(yǎng),分子生物學(xué),免疫安全 經(jīng)營模式 工廠,試劑
  • 上海一研生物科技有限公司
VIP 3年
  • 公司成立:11年
  • 注冊資本:100
  • 企業(yè)類型:營業(yè)執(zhí)照
  • 主營產(chǎn)品:、ELISA試劑盒、PCR檢測試劑盒、生化檢測試劑盒、標(biāo)準(zhǔn)品、抗體、細(xì)胞等
  • 公司地址:上海市閔行區(qū)莘福路2號樓
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