產品屬性:
產品名稱 | 規(guī)格 | CAS號 | 型號 |
3-Phenyltoxoflavin | 5g 10mg 25mg 50mg 100mg | 32502-63-9 | EY-Y0163533 |
Cas No.32502-63-9
別名 N/A
化學名 N/A
分子式 C13H11N5O2
分子量 269.26
溶解度 DMSO: 7.14 mg/mL (26.52 mM)
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述:
3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].
3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1].3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].
[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54. [2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.
關鍵字: 32502-63-9;C13H11N5O2;3-Phenyltoxoflavin;
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