中文名稱
英文名字
Recombinant Human Matrix Metalloproteinase-7, Active
供應(yīng)商
ProSpec
產(chǎn)品貨號
ENZ-271
背景資料
Matrix metalloproteinase-7(MMP-7) also known as matrilysin and PUMP(EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas.
序列
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來源宿主
大腸桿菌中重組表達(dá)
溶解建議
提供的人基質(zhì)金屬蛋白酶-7(MMP 7)產(chǎn)品為滅菌的透明溶液;其中人基質(zhì)金屬蛋白酶-7(MMP 7)產(chǎn)品溶解于10mM HEPES(pH 7.4), 5mM CaCl2,150mM NaCl溶液中.
保存建議
人基質(zhì)金屬蛋白酶-7(MMP 7)溶液可以在4℃冷藏保存3周;如果想延長保存時間,建議分裝后置于-18℃凍存.請避免反復(fù)凍融.
其他
ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司,具有20多年的生產(chǎn)經(jīng)驗(yàn),專注于蛋白(重組及合成)生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括:干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白,價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白,而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液,ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽,這就對工藝提出了更高的要求。同時,ProSpec-Tany絕大部分產(chǎn)品為凍干粉,因此易于運(yùn)輸和保存。
湖北艾普蒂生物工程有限公司
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